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川芎嗪

分析標(biāo)準(zhǔn)品,HPLC≥98%

Tetramethylpyrazine

CAS號：1124-11-4

分子式：C8H12N2

分子量：136.19

MDL：MFCD00006146

別名：川芎嗪,四甲基吡嗪; 2,3,5,6-四甲基哌嗪; 2,3,5,6-四甲基; 2,3,5,6-四甲基吡嗪;;2,3,5,6-tetramethylpyrazine; Pyrazine, tetramethyl-

產(chǎn)品介紹

熔點(diǎn)：82-86℃

沸點(diǎn)：190℃

溶解性：DMSO：25mg/ml

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(32篇)

32. [IF=5] Shaoyu Guan et al."Ligustrazine Alleviates Blood–Brain Barrier Damage by Downregulating Expression of miR‐297c‐5p."CNS Neuroscience & Therapeutics.2025 May;31(5):e70367

31. [IF=9.7] Jiashuai Hu et al."Synthesis of hydrothermal carbonation carbon with tunable photocatalytic performance for trimethoprim degradation using an ethanol-water co-solvent strategy: Influence of ethanol concentration."Journal of Cleaner Production.2024 Oct;:14

30. [IF=4.8] Junjie Chen et al."A novel framework for uncovering the coordinative spectrum-effect correlation of the effective components of Yangyin Tongnao Granules on cerebral ischemia-reperfusion injury in rats."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jan;337:118844

29. [IF=1.1] Tailiang Lu et al."Cinnamic acid derivatives played a major role in the resistance of peach leaves to Xanthomonas arboricola pv. pruni infection."JOURNAL OF PHYTOPATHOLOGY.2024 Aug;172(4):e13369

28. [IF=4] Min Gou et al."Identification and formation of key aroma-active compounds in red jujube as affected by different processing methods."JOURNAL OF FOOD COMPOSITION AND ANALYSIS.2024 Nov;135:106694

27. [IF=3.2] Mengke Sheng et al."A hybrid evaluation of the intestinal absorption performance of compounds from molecular structure."Chemical Biology & Drug Design.2024 Jul;104(1):e14576

26. [IF=4.6] Yalan Pan et al."Composite Hydrogel Containting Collagen-Modified Polylactic Acid-hydroxylactic acid Copolymer Microspheres Loaded with Tetramethylpyrazine Promotes Articular Cartilage Repair."MACROMOLECULAR BIOSCIENCE".2024 Apr;:2400003

25. [IF=10] Congyan Liu et al."A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms."Advanced Healthcare Materials".2024 Mar;:2303659

24. [IF=8.8] Yanmei Zhu et al."Authenticity identification of high – Temperature Daqu Baijiu through multi-channel visual array sensor of organic dyes combined with smart phone App."FOOD CHEMISTRY.2023 Nov;:137980

23. [IF=4.6] Chen Songmao et al."Protective effect of ligustrazine on oxidative stress and apoptosis following testicular torsion in rats."Scientific Reports.2023 Nov;13(1):1-8

22. [IF=10.7] Chunfang Zhao et al."An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds."Journal of Advanced Research.2023 Nov;:

21. [IF=4.6] Fei Zhou et al."Inhibiting autophagy to boost antitumor immunity with tetramethylpyrazine-loaded and PD-L1-targeting Liposomal Nanoparticles."EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES.10.1016/j.ejps.2023.106581

20. [IF=5.8] Xingru Peng et al."Novel mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism."COLLOIDS AND SURFACES B-BIOINTERFACES.10.1016/j.colsurfb.2023.113560

19. [IF=9.9] Huifang Ge et al."Ligusticum chuanxiong prevents high-fat-diet-induced lipid metabolism disorder in mice by modulating the genes in the cholesterol pathway."Food Frontiers.2023 Jun;:

18. [IF=5.988] Sa Li et al."Suxiao Jiuxin Pill attenuates acute myocardial ischemia via regulation of coronary artery tone."Frontiers in Pharmacology.2023; 14: 1104243

17. [IF=9.231] Min Gou et al."Novel insight into the evolution of volatile compounds during dynamic freeze-drying of Ziziphus jujuba cv. Huizao based on GC-MS combined with multivariate data analysis."FOOD CHEMISTRY.2022 Dec;:135368

16. [IF=4.52] Min Gou et al."Key aroma-active compounds identification of Ziziphus jujuba cv. Huizao: Effect of pilot scale freeze-drying."JOURNAL OF FOOD COMPOSITION AND ANALYSIS.2023 Mar;116:105072

15. [IF=5.395] Yu Wen et al."Ligustrazine-Loaded Borneol Liposome Alleviates Cerebral Ischemia–Reperfusion Injury in Rats."ACS Biomaterials Science & Engineering.2022;XXXX(XXX):XXX-XXX

14. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

13. [IF=2.629] Guan Baoyi et al."Antiplatelet Activity of Tetramethylpyrazine via Regulation of the P2Y12 Receptor Downstream Signaling Pathway."Evid-Based Compl Alt. 2022;2022:7941039

12. [IF=5.81] Jiang  Yue-Peng et al."Inconsistent Time-Dependent Effects of Tetramethylpyrazine on Primary Neurological Disorders and Psychiatric Comorbidities."Front Pharmacol. 2021 Aug;0:1957

11. [IF=5.875] Sirui Xiao et al."Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention."Int J Pharmaceut. 2020 Feb;575:118962

10. [IF=1.984] Yuan Rong et al."Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-Induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways."Evid-Based Compl Alt. 2018;2018:3082507

9. [IF=3.038] Shao  Zhengkai et al."Tetramethylpyrazine Protects Against Early Brain Injury and Inhibits the PERK/Akt Pathway in a Rat Model of Subarachnoid Hemorrhage."Neurochem Res. 2018 Aug;43(8):1650-1659

8.  劉明宗,劉于嵩,龍國利,張釗,江宇虹,高榕茂.川芎嗪調(diào)控miR-31-5p/Ednrb通路抑制人肺泡上皮細(xì)胞BEAS-2B凋亡和炎癥反應(yīng)[J].中成藥,2021,43(03):617-624.

7.  鐘桂芳,張帆,郭輝祥,周憶菲,馬歌麗,王光路.高溫大曲中產(chǎn)四甲基吡嗪細(xì)菌的篩選及鑒定[J].中國釀造,2020,39(08):107-111.

6.  李冬靜,李欣宇,楊陽,封國溧,王志翀,張文君.川芎嗪BCA-PLGA納米粒的制備工藝研究[J].哈爾濱商業(yè)大學(xué)學(xué)報(bào)(自然科學(xué)版),2020,36(04):387-392.

5.  鐘桂芳、張帆、郭輝祥、周憶菲、馬歌麗、王光路. 高溫大曲中產(chǎn)四甲基吡嗪細(xì)菌的篩選及鑒定[J]. 中國釀造, 2020, v.39;No.342(08):111-115.

4.  宋精梅, 陳思邈, 陳冰,等. 川芎苦參不同比例配伍對活性成分和抗氧化活性的影響[J]. 中國中醫(yī)急癥, 2020(1):87-90.

3.  黎峰, 黃成, 李俊. 川芎嗪對肝星狀細(xì)胞凋亡的影響及機(jī)制研究[J]. 安徽醫(yī)科大學(xué)學(xué)報(bào), 2017, 52(012):1773-1777.

2.  張文君, 王晴, 張國鋒,等. 川芎嗪雙包載納米粒的處方優(yōu)化及體外釋藥行為研究[J]. 中藥新藥與臨床藥理, 2019, v.30;No.165(12):121-125.

1.  李冬靜, 李欣宇, 楊陽,等. 川芎嗪BCA-PLGA納米粒的制備工藝研究. 哈爾濱商業(yè)大學(xué)學(xué)報(bào)(自然科學(xué)版).

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